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KMID : 0380319890440000085
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Journal of Korean Research Institute for Better Living
1989 Volume.44 No. 0 p.85 ~ p.90
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A Study on the Prevalence of Vitamin K Deficiency of Newborns with PIVKAL & Hepaplastin Tests and the Effect after Administration of Vitamin K
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Abstract
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The Prevalence of Vitamin K deficiency in newborns was studied from June 1989 to July 1989.
PIVKA-Ⅱ(protein induced vitamin K abscence) is abnormal decarboxylated prothrombin which is present in vitamin K deficiency.
We gave PIVKAL test in order to detect PIVKA-Ⅱ and tried Hepaplastin test to evaluate coagulation activity.
We obtained umbilical plasma from thirty normal full term newborns, and also obtained venous plasma from them three days after vitamin K administration.
Following are the results of the tests.
1. PIVKA-Ⅱ was found in the cord blood of nine and was disappeared in the venous blood.
2. Abnormally low values of HPT(<30%) with PIVKA-Ⅱ＋ were five normal values of HPT (>30%) with PIVKA-Ⅱ＋ were four, low values of HPT with PIVKA-Ⅱ- were eight, and normal values of HPT with PIVKA-Ⅱ- were thirteen.
3. The mean values±SD of HPT with PIVKA-Ⅱ＋ group were 27.56±10.85, and 31.37±12.28 with PIVKA-Ⅱ- group from cord blood. The mean values±SD of HPT with PIVKA-Ⅱ＋ group were 53.78±14.96 and 55.86±17.48 with PIVKA- group from venous blood.
4. The mean value of differences between cord blood and venous blood from HPT among all the newborns were 25.1±17.88, 26.2±5.93 among PIVKA-Ⅱ＋newborns, and 24.49±19.00 among PIVKA-Ⅱ- newborns. There was no significant statistical difference among three groups.
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